Cell cycle duration changes dramatically during development, starting out fast to generate cells quickly and slowing down over time as the organism matures.The cell cycle can also act as a transcriptional filter to control the expression of long gene transcripts, which are partially transcribed in short cycles.Using mathematical simulations of cell
Background MotherSafe is a free telephone-based counseling service for Australian consumers and health-care providers concerned about drug exposures during pregnancy and breastfeeding.Anti-infectives are the most commonly prescribed drugs for pregnant women.This study aims to provide a descriptive analysis of prospectively collected calls received
Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors.They interact with nuclear receptors using short linear motifs (SLiMs) termed co-repressor for nuclear receptor (CoRNR) boxes.Here, we identify the pathway leading to increasing
This article presents the application of soft computing methods for solving the problem of designing and optimizing cloud-based Content Distribution Networks (CDN).A multi-objective approach is applied to solve the resource provisioning problem for building the infrastructure for the network, considering the objectives of minimizing the cost of the